Polymorphisms in TREX1 and susceptibility to HIV-1 infection

A Pontillo; M Girardelli; E Catamo; A J Duarte; S Crovella

doi:10.1111/iji.12071

Polymorphisms in TREX1 and susceptibility to HIV-1 infection

Int J Immunogenet. 2013 Dec;40(6):492-4. doi: 10.1111/iji.12071. Epub 2013 Jun 15.

Authors

A Pontillo¹, M Girardelli, E Catamo, A J Duarte, S Crovella

Affiliation

¹ Department of Immunology, Institute of Biologic Sciences, University of Sao Paulo, Sao Paulo, Brazil.

PMID: 23773365
DOI: 10.1111/iji.12071

Abstract

TREX-1 is a restriction factor against HIV-1. The coding sequence of TREX1 gene was analysed in HIV+ subjects searching for genetic variations possibly associated with the susceptibility to HIV infection. The single nucleotide polymorphism rs3135945 was significantly associated with HIV infection, emphasizing the involvement of TREX-1 in the anti-HIV response.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Alleles
Exodeoxyribonucleases / genetics*
Gene Frequency
Genetic Predisposition to Disease / genetics*
Genotype
HIV Infections / genetics*
HIV Infections / virology
HIV-1*
Humans
Middle Aged
Odds Ratio
Phosphoproteins / genetics*
Polymorphism, Single Nucleotide*
Young Adult

Substances

Phosphoproteins
Exodeoxyribonucleases
three prime repair exonuclease 1