Abstract
Oncogene-driven adaptation of metabolism during tumorigenesis includes steps that stimulate the uptake of nutrients, especially glucose and glutamine, to sustain cell growth and proliferation. Macropinocytosis, a clathrin- and caveolin-independent endocytotic process that had previously been linked to the action of oncogenic Ras and Src, is now shown to contribute to amino acid uptake via enhanced delivery of extracellular proteins to lysosomes.
MeSH terms
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Caveolin 1 / metabolism
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Clathrin / metabolism
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Endocytosis / physiology*
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Glucose / metabolism
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Glutamine / metabolism
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Humans
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Lysosomes / metabolism
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Mechanistic Target of Rapamycin Complex 1
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Multiprotein Complexes / metabolism
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Phosphatidylinositol 3-Kinases / metabolism
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TOR Serine-Threonine Kinases / metabolism
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ras Proteins / metabolism*
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src-Family Kinases / metabolism
Substances
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Caveolin 1
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Clathrin
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Multiprotein Complexes
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Glutamine
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src-Family Kinases
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Mechanistic Target of Rapamycin Complex 1
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TOR Serine-Threonine Kinases
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ras Proteins
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Glucose