Microbubbles from gas-generating perfluorohexane nanoemulsions for targeted temperature-sensitive ultrasonography and synergistic HIFU ablation of tumors

Adv Mater. 2013 Aug 14;25(30):4123-30. doi: 10.1002/adma.201301655. Epub 2013 Jun 21.

Abstract

A special "small to big" temperature-responsive phase-transformation strategy based on the "acoustic droplet vaporization (ADV)" mechanism is developed for efficient targeted ultrasonography and synergistic high intensity focused ultrasound (HIFU) cancer surgery by engineering targeted nanoemulsions, which is systematically evaluated and successfully demonstrated in vitro, ex vivo, and in vivo.

Keywords: high intensity focused ultrasound (HIFU); nanotechnology; phase transformations; tumors; ultrasound imaging.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line, Tumor
  • Emulsions / chemistry
  • Emulsions / therapeutic use
  • Fluorocarbons / chemical synthesis*
  • Fluorocarbons / therapeutic use*
  • Gases / chemical synthesis
  • Gases / therapeutic use
  • High-Intensity Focused Ultrasound Ablation / methods*
  • Materials Testing
  • Mice
  • Mice, Nude
  • Microbubbles / therapeutic use
  • Nanoparticles / chemistry*
  • Nanoparticles / therapeutic use*
  • Nanoparticles / ultrastructure
  • Neoplasms, Experimental / pathology*
  • Neoplasms, Experimental / therapy*
  • Temperature
  • Treatment Outcome

Substances

  • Emulsions
  • Fluorocarbons
  • Gases
  • perflexane