Inside-out connections: the ER meets the plasma membrane

Cell. 2013 Jun 20;153(7):1423-4. doi: 10.1016/j.cell.2013.05.054.

Abstract

Junctions that connect the endoplasmic reticulum (ER) and the plasma membrane (PM) are unique yet ubiquitous subcellular compartments. Giordano et al. now report that extended synaptotagmins (E-Syts) promote their formation, providing fundamental insight into the molecular machinery controlling ER and plasma membrane crosstalk.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Calcium / metabolism*
  • Cell Membrane / metabolism*
  • Endoplasmic Reticulum / metabolism*
  • Humans
  • Phosphatidylinositol 4,5-Diphosphate / metabolism*
  • Synaptotagmins / metabolism*

Substances

  • ESYT1 protein, human
  • ESYT2 protein, human
  • ESYT3 protein, human
  • Phosphatidylinositol 4,5-Diphosphate
  • Synaptotagmins
  • Calcium