Characterization of Farmington virus, a novel virus from birds that is distantly related to members of the family Rhabdoviridae

Virol J. 2013 Jul 1:10:219. doi: 10.1186/1743-422X-10-219.

Abstract

Background: Farmington virus (FARV) is a rhabdovirus that was isolated from a wild bird during an outbreak of epizootic eastern equine encephalitis on a pheasant farm in Connecticut, USA.

Findings: Analysis of the nearly complete genome sequence of the prototype CT AN 114 strain indicates that it encodes the five canonical rhabdovirus structural proteins (N, P, M, G and L) with alternative ORFs (> 180 nt) in the N and G genes. Phenotypic and genetic characterization of FARV has confirmed that it is a novel rhabdovirus and probably represents a new species within the family Rhabdoviridae.

Conclusions: In sum, our analysis indicates that FARV represents a new species within the family Rhabdoviridae.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Bird Diseases / virology*
  • Birds
  • Chlorocebus aethiops
  • Cluster Analysis
  • Connecticut
  • Gene Order
  • Molecular Sequence Data
  • Open Reading Frames
  • Phylogeny
  • Rhabdoviridae / classification*
  • Rhabdoviridae / genetics
  • Rhabdoviridae / isolation & purification*
  • Rhabdoviridae Infections / veterinary*
  • Rhabdoviridae Infections / virology
  • Sequence Analysis, DNA
  • Vero Cells
  • Viral Proteins / genetics

Substances

  • Viral Proteins

Associated data

  • GENBANK/KC602379