Abstract
Propranolol is a well-known powerful betareceptor-blocking agent. Its quaternary dimethyl derivative, designated as pranolium was firstly prepared by Lucchesi. Compared to propranolol it possesses no betareceptor-blocking activity and no local anaesthetic properties but shows the same antiarrhythmic action as the starting material. The synthesis of pranolium and its optical isomers starting from the corresponding propranolol derivatives is described. Their pharmacological activities have been tested. No significant differences regarding the pharmacological action could be observed.
MeSH terms
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Aconitine
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Animals
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Anti-Arrhythmia Agents / chemical synthesis*
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Chemical Phenomena
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Chemistry
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Coronary Disease / chemically induced
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Coronary Disease / prevention & control
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Female
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Glycogen / metabolism
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Guinea Pigs
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Heart / drug effects
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In Vitro Techniques
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Isomerism
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Isoproterenol / pharmacology
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Magnetic Resonance Spectroscopy
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Male
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Mass Spectrometry
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Propranolol / analogs & derivatives*
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Propranolol / analysis
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Propranolol / chemical synthesis
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Propranolol / pharmacology
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Rats
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Rats, Inbred Strains
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Spectrophotometry, Infrared
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Spectrophotometry, Ultraviolet
Substances
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Anti-Arrhythmia Agents
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pranolium
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Glycogen
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Propranolol
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Isoproterenol
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Aconitine