Multiple samples improve the sensitivity for detection of mixed Mycobacterium infections

Tuberculosis (Edinb). 2013 Sep;93(5):548-50. doi: 10.1016/j.tube.2013.06.002. Epub 2013 Jul 6.

Abstract

By using VNTR genotyping, mixed infections of Mycobacterium tuberculosis were detected in 11.2% of cases in a prospective study in Heilongjiang China, a setting with a high prevalence (87.5%) of Beijing family strains. If only one sputum sample had been collected, the study would have underestimated the fraction of mixed infections by 50%.

Keywords: Drug resistance; Mixed infections; Multiple sampling; Mycobacterium tuberculosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Bacterial Typing Techniques
  • China / epidemiology
  • Female
  • Genotyping Techniques / methods
  • Humans
  • Male
  • Microbial Sensitivity Tests
  • Middle Aged
  • Minisatellite Repeats / genetics
  • Mycobacterium tuberculosis / classification*
  • Mycobacterium tuberculosis / drug effects
  • Mycobacterium tuberculosis / genetics
  • Mycobacterium tuberculosis / isolation & purification
  • Prospective Studies
  • Sensitivity and Specificity
  • Specimen Handling / methods
  • Sputum / microbiology*
  • Tuberculosis, Pulmonary / epidemiology
  • Tuberculosis, Pulmonary / microbiology*
  • Young Adult