Enhanced efficacy and broadening of antibacterial action of drugs via the use of capped mesoporous nanoparticles

Chemistry. 2013 Aug 19;19(34):11167-71. doi: 10.1002/chem.201302170. Epub 2013 Jul 9.

Abstract

Bug busters: A novel nanodevice consisting of mesoporous nanoparticles loaded with vancomycin and capped with ε-poly-L-lysine (ε-PL) was prepared and its interaction with different Gram-negative bacteria studied. A remarkable improvement in the efficacy of the antimicrobial drug ε-PL and a broadening of the antimicrobial spectrum of vancomycin is demonstrated.

Keywords: gated materials; mesoporous materials; nanoparticles; vancomycin; ε-poly-L-lysine.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / chemistry*
  • Anti-Bacterial Agents / pharmacology
  • Drug Carriers / chemistry
  • Drug Carriers / pharmacology
  • Gram-Negative Bacteria / drug effects
  • Microbial Sensitivity Tests
  • Nanoparticles / chemistry*
  • Polylysine / chemistry
  • Porosity
  • Silicon Dioxide / chemistry
  • Vancomycin / chemistry*

Substances

  • Anti-Bacterial Agents
  • Drug Carriers
  • MCM-41
  • Polylysine
  • Vancomycin
  • Silicon Dioxide