[New synthesis of highly selective inhibitor of histone deacetylase 6--N-hydroxy-4-(2-methyl-1,2,3,4-tetrahydro-pyrido[4,3b]indol-5-ylmethyl)benzamide--Tubastatin A]

M V Kozlov; A A Kleĭmenova; K A Konduktorov; S N Kochetkov

doi:10.1134/s1068162012060076

[New synthesis of highly selective inhibitor of histone deacetylase 6--N-hydroxy-4-(2-methyl-1,2,3,4-tetrahydro-pyrido[4,3b]indol-5-ylmethyl)benzamide--Tubastatin A]

Bioorg Khim. 2013 Jan-Feb;39(1):117-20. doi: 10.1134/s1068162012060076.

[Article in Russian]

Authors

M V Kozlov, A A Kleĭmenova, K A Konduktorov, S N Kochetkov

PMID: 23844513
DOI: 10.1134/s1068162012060076

Abstract

A four-stage synthesis of highly selective inhibitor of histone deacetylase 6--Tubastatin A was carried out. Convenient and safety reaction conditions were used throughout the synthesis.

MeSH terms

Benzamides / chemistry
Histone Deacetylase Inhibitors / chemical synthesis*
Histone Deacetylase Inhibitors / chemistry
Histone Deacetylases / chemistry
Histone Deacetylases / metabolism*
Hydroxamic Acids / chemical synthesis*
Hydroxamic Acids / chemistry
Indoles / chemical synthesis*
Indoles / chemistry
Molecular Structure

Substances

Benzamides
Histone Deacetylase Inhibitors
Hydroxamic Acids
Indoles
tubastatin A
benzamide
Histone Deacetylases