Autoimmune lymphoproliferative syndrome and non-Hodgkin lymphoma: what 18F-fluorodeoxyglucose positron emission tomography/computed tomography can do in the management of these patients? Suggestions from a case report

Rev Esp Med Nucl Imagen Mol. 2014 Mar-Apr;33(2):99-102. doi: 10.1016/j.remn.2013.05.008. Epub 2013 Jul 9.

Abstract

A young patient with undefined autoimmune lymphoproliferative syndrome (ALPS-U) and low back pain underwent a CT and MRI study that showed enhancing vertebral lesions, some pulmonary nodules and diffuse latero-cervical lymphadenopathy. A (18)F-FDG-PET/CT scan showed many areas of intense (18)F-FDG uptake in multiple vertebrae, in some ribs, in the sacrum, in the liver, in both lungs, in multiple lymph nodes spread in the cervical, thoracic and abdominal chains. A bone marrow biopsy showed a "lymphomatoid granulomatosis", a rare variant of B-cell non-Hodgkin lymphoma (NHL). After the treatment, the (18)F-FDG-PET/CT scan showed a complete metabolic response.

Keywords: Autoimmune lymphoproliferative syndrome; Fas gene; Gen Fas; Linfoma no Hodgkin; Non-Hodgkin lymphoma; PET; Rituximab; Síndrome linfoproliferativo autoinmune.

Publication types

  • Case Reports
  • Evaluation Study

MeSH terms

  • Adult
  • Autoimmune Lymphoproliferative Syndrome / diagnosis*
  • Autoimmune Lymphoproliferative Syndrome / therapy*
  • Fluorodeoxyglucose F18*
  • Humans
  • Lymphoma, Non-Hodgkin / diagnosis*
  • Lymphoma, Non-Hodgkin / therapy*
  • Male
  • Multimodal Imaging*
  • Positron-Emission Tomography*
  • Radiopharmaceuticals*
  • Tomography, X-Ray Computed*

Substances

  • Radiopharmaceuticals
  • Fluorodeoxyglucose F18