A new cytotoxic cembrane diterpene from the roots of Euphorbia pekinensis Rupr

Fitoterapia. 2013 Oct:90:10-3. doi: 10.1016/j.fitote.2013.07.004. Epub 2013 Jul 10.

Abstract

A new cembrane diterpene, named (-)-(1S)-15-hydroxy-18-carboxycembrene, was isolated from petroleum ether extract of the roots of the Euphorbia pekinensis Rupr. To our knowledge, this compound is the first cembrane-type diterpenoid to be found in the family Euphorbiaceae. The structure was elucidated as (-)-(1S)-15-hydroxy-cembra -2E, 4Z, 7E, 11E-tetraen-18-oic acid by a combination of IR, HR-ESIMS, 1D- and 2D-NMR techniques. (-)-(1S)-15-hydroxy-18-carboxycembrene showed cytotoxic activity against all five human cancer cell lines tested.

Keywords: (−)-(1S)-15-hydroxy-18-carboxycembrene; Cembrane-type diterpene; Cytotoxic activity; Euphorbia pekinensis Rupr..

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Antineoplastic Agents, Phytogenic / therapeutic use
  • Cell Line, Tumor
  • Diterpenes / chemistry
  • Diterpenes / isolation & purification*
  • Diterpenes / pharmacology
  • Diterpenes / therapeutic use
  • Euphorbia / chemistry*
  • Humans
  • Molecular Structure
  • Neoplasms / drug therapy
  • Phytotherapy
  • Plant Extracts / chemistry*
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use
  • Plant Roots

Substances

  • (-)-(1S)-15-hydroxy-18-carboxycembrene
  • Antineoplastic Agents, Phytogenic
  • Diterpenes
  • Plant Extracts