Abstract
Six new cardenolides (1, 2 and 11-14), along with ten known ones, were isolated from the root bark of Calotropis gigantea. The structural determination was accomplished by the 1D- and 2D-NMR spectrum as well as ESIMS analysis. The isolated compounds were evaluated for their in vitro growth inhibitory activity against human A549 and Hela cell lines. The results suggested that some of these cardenolides (compounds 1, 6, and 8) displayed potent cytotoxicities.
Keywords:
Antitumor agent; Asclepiadaceae; Calotropis gigantea; Cardenolide; Cytotoxicity.
Copyright © 2013 Elsevier Inc. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology*
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Calotropis / chemistry*
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Cardenolides / chemistry
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Cardenolides / isolation & purification
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Cardenolides / pharmacology*
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Cell Survival / drug effects
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Drug Screening Assays, Antitumor
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HeLa Cells
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Humans
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Inhibitory Concentration 50
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Plant Bark / chemistry*
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Plant Extracts / chemistry
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology*
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Plant Roots / chemistry*
Substances
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Antineoplastic Agents, Phytogenic
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Cardenolides
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Plant Extracts