Abstract
A facile and efficient one-pot synthesis of β-hydroxy-γ-lactams from α,α-dialkyl β-oxo amides and trimethylsulfoxonium iodide in the presence of sodium hydride via a tandem Corey-Chaykovsky reaction and an intramolecular lactamization process is developed.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amides / chemistry*
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Sodium Compounds / chemistry
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Sulfonium Compounds / chemistry*
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beta-Lactams / chemical synthesis*
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beta-Lactams / chemistry
Substances
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Amides
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Sodium Compounds
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Sulfonium Compounds
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beta-Lactams
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dimethylsulfoxonium methylide
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sodium hydride