Tumor fibroblast specific activation of a hybrid ferritin nanocage-based optical probe for tumor microenvironment imaging

Tianjiao Ji; Ying Zhao; Jing Wang; Xin Zheng; Yanhua Tian; Yuliang Zhao; Guangjun Nie

doi:10.1002/smll.201300600

Tumor fibroblast specific activation of a hybrid ferritin nanocage-based optical probe for tumor microenvironment imaging

Small. 2013 Jul 22;9(14):2427-31. doi: 10.1002/smll.201300600.

Authors

Tianjiao Ji¹, Ying Zhao, Jing Wang, Xin Zheng, Yanhua Tian, Yuliang Zhao, Guangjun Nie

Affiliation

¹ Chinese Academy of Sciences Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, China, Beijing 100190, China.

PMID: 23853124
DOI: 10.1002/smll.201300600

Abstract

Ferritin-based FAP-α-responsive fluorescence nanoprobes could be activated immediately as they penetrate the tumor blood vessels and come across the FAP-α molecules on the membrane of CAFs in the tumor microenvironment instead of reaching a certain depth into tumor tissue to interact with tumor cells. This probe may become a promising nanomaterial for highly specific and sensitive tumor imaging through responding to the enzymes in the tumor microenvironment.

Keywords: cancer-associated fibroblasts; ferritin; fibroblast activation protein-α; imaging; nanotechnology.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Line, Tumor
Ferritins / chemistry*
Fibroblasts / cytology
Humans
Male
Microscopy, Electron, Transmission
Nanostructures*
Neoplasms / pathology*
Tumor Microenvironment*

Substances

Ferritins