Mycalol: a natural lipid with promising cytotoxic properties against human anaplastic thyroid carcinoma cells

Angew Chem Int Ed Engl. 2013 Aug 26;52(35):9256-60. doi: 10.1002/anie.201303039. Epub 2013 Jul 15.
No abstract available

Keywords: NMR spectroscopy; configuration determination; cytotoxicity; lipids; natural products.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification
  • Antineoplastic Agents / pharmacology*
  • Biological Products / chemistry
  • Biological Products / isolation & purification
  • Biological Products / pharmacology*
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Cell Survival / drug effects
  • Dose-Response Relationship, Drug
  • Drug Screening Assays, Antitumor
  • Fatty Alcohols / chemistry
  • Fatty Alcohols / isolation & purification
  • Fatty Alcohols / pharmacology*
  • Humans
  • Molecular Conformation
  • Porifera / chemistry
  • Structure-Activity Relationship
  • Thyroid Neoplasms / drug therapy*
  • Thyroid Neoplasms / pathology*

Substances

  • Antineoplastic Agents
  • Biological Products
  • Fatty Alcohols
  • mycalol