pocrm: an R-package for phase I trials of combinations of agents

Comput Methods Programs Biomed. 2013 Oct;112(1):211-8. doi: 10.1016/j.cmpb.2013.05.020. Epub 2013 Jul 18.

Abstract

This paper presents the R package pocrm for implementing and simulating the partial order continual reassessment method (PO-CRM; [1,2]) in Phase I trials of combinations of agents. The aim of this article is to illustrate, through examples of the pocrm package, how the PO-CRM works and how its operating characteristics can inform clinical trial investigators. This should promote the use of the PO-CRM in designing and conducting dose-finding Phase I trials of combinations of agents.

Keywords: Continual reassessment method; Dose finding; Drug combination; Partial ordering; Phase I trials.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / administration & dosage
  • Antineoplastic Agents / adverse effects
  • Antineoplastic Combined Chemotherapy Protocols / administration & dosage*
  • Antineoplastic Combined Chemotherapy Protocols / adverse effects
  • Cancer Vaccines / administration & dosage
  • Clinical Trials, Phase I as Topic / statistics & numerical data*
  • Computer Simulation
  • Freund's Adjuvant / administration & dosage
  • Humans
  • Lipids / administration & dosage
  • Maximum Tolerated Dose
  • Melanoma / therapy
  • Neoplasms / drug therapy*
  • Software*
  • Toll-Like Receptors / agonists

Substances

  • Antineoplastic Agents
  • Cancer Vaccines
  • Lipids
  • Toll-Like Receptors
  • incomplete Freund's adjuvant
  • Freund's Adjuvant