Nanoparticle-programmed self-destructive neural stem cells for glioblastoma targeting and therapy

Small. 2013 Dec 20;9(24):4123-9. doi: 10.1002/smll.201301111. Epub 2013 Jul 21.

Abstract

A 3-step glioblastoma-tropic delivery and therapy method using nanoparticle programmed self-destructive neural stem cells (NSCs) is demonstrated in vivo: 1) FDA-approved NSCs for clinical trials are loaded with pH-sensitive MSN-Dox; 2) the nanoparticle conjugates provide a delayed drug-releasing mechanism and allow for NSC migration towards a distant tumor site; 3) NSCs eventually undergo cell death and release impregnated MSN-Dox, which subsequently induces toxicity towards surrounding glioma cells.

Keywords: doxorubicin; drug delivery; glioblastoma; glioma; mesoporous silica nanoparticles; neural stem cells; targeted delivery.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Apoptosis
  • Brain Neoplasms / therapy*
  • Cell Death
  • Cell Line, Tumor
  • Cell Movement
  • Clinical Trials as Topic
  • Doxorubicin / administration & dosage
  • Drug Delivery Systems
  • Glioblastoma / therapy*
  • Humans
  • Hydrogen-Ion Concentration
  • Lysosomes
  • Mice
  • Microscopy, Electron, Transmission
  • Microscopy, Fluorescence
  • Nanomedicine
  • Nanoparticles / chemistry*
  • Neoplasm Transplantation
  • Neural Stem Cells / cytology*
  • Neural Stem Cells / ultrastructure

Substances

  • Doxorubicin