RflM functions as a transcriptional repressor in the autogenous control of the Salmonella Flagellar master operon flhDC

J Bacteriol. 2013 Sep;195(18):4274-82. doi: 10.1128/JB.00728-13. Epub 2013 Jul 19.

Abstract

Motility of bacteria like Salmonella enterica is a highly regulated process that responds to a variety of internal and external stimuli. A hierarchy of three promoter classes characterizes the Salmonella flagellar system, and the onset of flagellar gene expression depends on the oligomeric regulatory complex and class 1 gene product FlhD(4)C(2). The flhDC promoter is a target for a broad range of transcriptional regulators that bind within the flhDC promoter region and either negatively or positively regulate flhDC operon transcription. In this work, we demonstrate that the RflM protein is a key component of flhDC regulation. Transposon mutagenesis was performed to investigate a previously described autoinhibitory effect of the flagellar master regulatory complex FlhD(4)C(2). RflM is a LuxR homolog that functions as a flagellar class 1 transcriptional repressor. RflM was found to be the negative regulator of flhDC expression that is responsible for the formerly described autoinhibitory effect of the FlhD(4)C(2) complex on flhDC operon transcription (K. Kutsukake, Mol. Gen. Genet. 254:440-448, 1997). We conclude that upon commencement of flagellar gene expression, the FlhD(4)C(2) complex initiates a regulatory feedback loop by activating rflM gene expression. rflM encodes a transcriptional repressor, RflM, which fine-tunes flhDC expression levels.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacterial Proteins / genetics*
  • Bacterial Proteins / metabolism
  • DNA Transposable Elements / genetics
  • Down-Regulation
  • Flagella / genetics
  • Flagella / metabolism*
  • Flagella / physiology
  • Gene Expression Regulation, Bacterial*
  • Genes, Regulator*
  • Mutagenesis, Insertional
  • Operon / drug effects*
  • Operon / genetics
  • Operon / physiology
  • Promoter Regions, Genetic
  • Salmonella typhimurium / genetics*
  • Salmonella typhimurium / metabolism
  • Salmonella typhimurium / physiology
  • Trans-Activators / genetics
  • Trans-Activators / metabolism*

Substances

  • Bacterial Proteins
  • DNA Transposable Elements
  • Trans-Activators