Abstract
The effect of intravenous infusion of aminophylline, a strong inhibitor of pyridoxal kinase, on intra- and extracellular vitamin B6 homeostasis was investigated in four beagle dogs. Plasma and erythrocyte pyridoxal levels increased by 118% and 117% respectively after 3 hours of aminophylline infusion, (4 mg/kg body weight/hour), however, infusion of beta-hydroxyethyltheophylline, which does not inhibit pyridoxal kinase, had no effect on either intra- or extracellular vitamin B6 aldehyde derivative levels. It is suggested that theophylline induced pyridoxal kinase inhibition resulted in a disturbed equilibrium between pyridoxal and pyridoxal 5'-phosphate.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaline Phosphatase / blood
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Alkaline Phosphatase / metabolism
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Aminophylline / administration & dosage
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Aminophylline / pharmacology*
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Animals
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Bronchodilator Agents / administration & dosage
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Bronchodilator Agents / pharmacology
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Dogs
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Erythrocytes / drug effects
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Erythrocytes / metabolism
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Homeostasis
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Infusions, Intravenous
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Pyridoxal Kinase / antagonists & inhibitors
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Pyridoxine / blood
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Pyridoxine / metabolism*
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Serum Albumin / metabolism
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Theophylline / administration & dosage
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Theophylline / analogs & derivatives
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Theophylline / pharmacology
Substances
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Bronchodilator Agents
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Serum Albumin
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Aminophylline
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Theophylline
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Pyridoxal Kinase
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Alkaline Phosphatase
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Pyridoxine
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etofylline