Abstract
New antifungal antibiotics, pradimicins A, B and C were isolated from the culture broth of actinomycete strains proposed as Actinomadura hibisca. They are orange to red pigments containing a benzo[a]naphthacenequinone chromophore substituted with a D-alanine, an aminosugar and a D-xylose (pradimicins A and C).
MeSH terms
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Actinomycetales / classification
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Actinomycetales / growth & development
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Actinomycetales / metabolism*
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Actinomycetales / ultrastructure
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Anthracyclines*
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Antibiotics, Antineoplastic / analysis
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Antibiotics, Antineoplastic / biosynthesis*
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Antibiotics, Antineoplastic / isolation & purification
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Antifungal Agents / analysis
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Antifungal Agents / biosynthesis*
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Antifungal Agents / isolation & purification
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Chromatography, High Pressure Liquid
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Crystallization
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Fermentation
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Magnetic Resonance Spectroscopy
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Microscopy, Electron
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Microscopy, Electron, Scanning
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Molecular Structure
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Soil Microbiology
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Spectrophotometry, Infrared
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Spectrophotometry, Ultraviolet
Substances
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Anthracyclines
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Antibiotics, Antineoplastic
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Antifungal Agents
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benanomicin B
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pradimicin A
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pradimicin B