Tuberous sclerosis complex 1 (hamartin) is an effective endogenous neuroprotectant. Understanding the endogenous mechanism for neuroprotection mediated by hamartin may afford a novel approach to effective treatment of neurological diseases such as stroke, neurodegenerative diseases, and epilepsy, with possible applications to nonneurological conditions.
Keywords: acute stroke therapy; hamartin; ischemic stroke; neuroprotection; productive autophagy; treatment.
© 2013 The Authors. International Journal of Stroke © 2013 World Stroke Organization.