Abstract
The non-hydrolyzable alkylcarbonate analogs of O-acetyl-ADP-ribose have been synthesized from the phosphorylated ribose derivatives after coupling with AMP morpholidate promoted by mechanical grinding. The analogs were assessed for their ability to inhibit the human sirtuin homolog SIRT1.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Carbonates / chemistry*
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Dose-Response Relationship, Drug
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Enzyme Inhibitors / chemical synthesis
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / pharmacology
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Humans
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Molecular Conformation
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O-Acetyl-ADP-Ribose / analogs & derivatives*
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O-Acetyl-ADP-Ribose / chemical synthesis*
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O-Acetyl-ADP-Ribose / chemistry
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O-Acetyl-ADP-Ribose / pharmacology
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Sirtuin 1 / antagonists & inhibitors
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Sirtuin 1 / metabolism
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Structure-Activity Relationship
Substances
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Carbonates
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Enzyme Inhibitors
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O-Acetyl-ADP-Ribose
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SIRT1 protein, human
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Sirtuin 1