Recombination is associated with an outbreak of novel highly pathogenic porcine reproductive and respiratory syndrome viruses in China

Mang Shi; Edward C Holmes; Manreetpal Singh Brar; Frederick Chi-Ching Leung

doi:10.1128/JVI.01270-13

Recombination is associated with an outbreak of novel highly pathogenic porcine reproductive and respiratory syndrome viruses in China

J Virol. 2013 Oct;87(19):10904-7. doi: 10.1128/JVI.01270-13. Epub 2013 Jul 24.

Authors

Mang Shi¹, Edward C Holmes, Manreetpal Singh Brar, Frederick Chi-Ching Leung

Affiliation

¹ Sydney Emerging Infections and Biosecurity Institute, School of Biological Sciences and Sydney Medical School, The University of Sydney, NSW, Australia.

Abstract

In 2009 to 2010, there was a marked increase in the number of infections with highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) in China. Through phylogenetic analysis, we show that viruses from this outbreak originated from a single recombination event, illustrating the potential importance of this process for disease emergence.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
China / epidemiology
Disease Outbreaks*
Genome, Viral*
Phylogeny
Porcine Reproductive and Respiratory Syndrome / epidemiology*
Porcine Reproductive and Respiratory Syndrome / genetics
Porcine Reproductive and Respiratory Syndrome / virology
Porcine respiratory and reproductive syndrome virus / pathogenicity*
RNA, Viral / genetics
Recombination, Genetic*
Swine

Substances

RNA, Viral