Increased CD4(+) T cell co-inhibitory immune receptor CEACAM1 in neonatal sepsis and soluble-CEACAM1 in meningococcal sepsis: a role in sepsis-associated immune suppression?

Michiel van der Flier; Dyana B Sharma; Silvia Estevão; Marieke Emonts; Denise Rook; Jan A Hazelzet; Johannes B van Goudoever; Nico G Hartwig

doi:10.1371/journal.pone.0068294

Increased CD4(+) T cell co-inhibitory immune receptor CEACAM1 in neonatal sepsis and soluble-CEACAM1 in meningococcal sepsis: a role in sepsis-associated immune suppression?

PLoS One. 2013 Jul 22;8(7):e68294. doi: 10.1371/journal.pone.0068294. Print 2013.

Authors

Michiel van der Flier¹, Dyana B Sharma, Silvia Estevão, Marieke Emonts, Denise Rook, Jan A Hazelzet, Johannes B van Goudoever, Nico G Hartwig

Affiliation

¹ Department of Pediatric Infectious Diseases and Immunology, Erasmus MC - Sophia, Rotterdam, The Netherlands. [email protected]

Abstract

The co-inhibitory immune receptor carcinoembryonic antigen-related cell-adhesion molecule 1 (CEACAM1) and its self-ligand CEACAM1 can suppress T cell function. Suppression of T cell function in sepsis is well documented. Late-onset neonatal sepsis in VLBW-infants was associated with an increased percentage CEACAM1 positive CD4(+) T-cells. Meningococcal septic shock in children was associated with increased serum soluble CEACAM1. In conclusion our data demonstrate increased surface expression of the co-inhibitory immune receptor CEACAM1 in late-onset neonatal sepsis in VLBW-infants, and increased circulating soluble CEACAM1 in children with meningococcal sepsis. Increased T-cell CEACAM1 expression and increased circulating soluble CEACAM1 may contribute to sepsis-associated immune suppression.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Antigens, CD / blood
Antigens, CD / chemistry
Antigens, CD / metabolism*
CD4-Positive T-Lymphocytes / immunology*
CD4-Positive T-Lymphocytes / metabolism*
Cell Adhesion Molecules / blood
Cell Adhesion Molecules / chemistry
Cell Adhesion Molecules / metabolism*
Child
Child, Preschool
Female
Gene Expression Regulation / immunology
Humans
Immune Tolerance*
Infant
Infant, Low Birth Weight / blood
Infant, Low Birth Weight / immunology
Infant, Newborn
Male
Meningococcal Infections / complications*
Sepsis / blood
Sepsis / complications
Sepsis / immunology*
Sepsis / metabolism*
Solubility

Substances

Antigens, CD
CD66 antigens
Cell Adhesion Molecules

Grants and funding

MvdF was supported by a Fellowship of the European Society of Paediatric Infectious Diseases (ESPID). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.