A self antigen reopens the games in pancreatic cancer

Oncoimmunology. 2013 Jun 1;2(6):e24384. doi: 10.4161/onci.24384. Epub 2013 May 10.

Abstract

We have recently demonstrated that the administration of a plasmid coding for α-enolase can elicit robust immune responses in genetically engineered mice that spontaneously develop pancreatic cancer, resulting in a significant improvement of their survival. This approach provides a springboard for the elaboration of new forms of immunotherapy for pancreatic cancer.

Keywords: DNA vaccination; cancer immunotherapy; mouse models; pancreatic cancer; α-enolase.