Detection of IP-10 protein marker in undiluted blood serum via an electrochemical E-DNA scaffold sensor

Analyst. 2013 Oct 7;138(19):5580-3. doi: 10.1039/c3an01079a.

Abstract

We describe an electrochemical analog of fluorescence polarization that supports the quantitative measurement of a specific protein, the chemokine IP-10, directly in undiluted blood serum. The sensor is label-free, wash-free, and electronic, suggesting it could support point-of-care detection of diagnostic proteins in largely unprocessed clinical samples.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomarkers / blood
  • Chemokine CXCL10 / analysis*
  • Chemokine CXCL10 / blood
  • DNA / chemistry*
  • DNA / metabolism
  • Electrochemical Techniques / methods*
  • Humans
  • Protein Structure, Secondary
  • Serum / chemistry*
  • Serum / metabolism

Substances

  • Biomarkers
  • CXCL10 protein, human
  • Chemokine CXCL10
  • DNA