Septins set the stage for Orai1 to bind STIM1 at ER-PM junctions

Dev Cell. 2013 Jul 29;26(2):116-8. doi: 10.1016/j.devcel.2013.07.012.

Abstract

The endoplasmic reticulum (ER) Ca(2+) sensor STIM1 recruits and activates the plasma membrane (PM) Ca(2+) channel Orai1 at ER-PM junctions for store-operated Ca(2+) entry (SOCE). Reporting in Nature, Sharma et al. (2013) showed that septins are necessary for Orai1 recruitment and SOCE, implicating these scaffolding proteins in signaling at ER-PM junctions.

Publication types

  • Comment

MeSH terms

  • Calcium / metabolism*
  • Humans
  • NFATC Transcription Factors / metabolism*
  • RNA Interference*
  • RNA, Small Interfering / genetics*
  • Septins / metabolism*

Substances

  • NFATC Transcription Factors
  • RNA, Small Interfering
  • Septins
  • Calcium