Abstract
Hippocampal interneurons receive GABAergic input from the medial septum. Using two-photon Ca(2+) imaging of axonal boutons in hippocampal CA1 of behaving mice, we found that populations of septo-hippocampal GABAergic boutons were activated during locomotion and salient sensory events; sensory responses scaled with stimulus intensity and were abolished by anesthesia. We found similar activity patterns among boutons with common putative postsynaptic targets, with low-dimensional bouton population dynamics being driven primarily by presynaptic spiking.
Publication types
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Research Support, Non-U.S. Gov't
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Video-Audio Media
MeSH terms
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Action Potentials / physiology
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Anesthetics, Local / pharmacology
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Animals
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Calmodulin / genetics
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Calmodulin / metabolism
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Channelrhodopsins
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Choline O-Acetyltransferase / metabolism
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Conditioning, Psychological
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DNA-Binding Proteins / genetics
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DNA-Binding Proteins / metabolism
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Glutamate Decarboxylase / genetics
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Glutamate Decarboxylase / metabolism
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Hippocampus / drug effects
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Hippocampus / physiology*
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In Vitro Techniques
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Mice
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Mice, Transgenic
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Motor Activity / drug effects
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Motor Activity / physiology
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Neural Pathways / drug effects
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Neural Pathways / physiology*
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Parvalbumins / genetics
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Parvalbumins / metabolism
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Plant Lectins / metabolism
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Proteins / genetics
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RNA, Untranslated
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Septum of Brain / cytology*
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Septum of Brain / drug effects
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Septum of Brain / physiology
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Signal Transduction / physiology*
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Tetrodotoxin / pharmacology
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Transcription Factors / genetics
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Transcription Factors / metabolism
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Wakefulness / physiology*
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gamma-Aminobutyric Acid / metabolism*
Substances
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Anesthetics, Local
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Calmodulin
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Channelrhodopsins
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DNA-Binding Proteins
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Grhl3 protein, mouse
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Gt(ROSA)26Sor non-coding RNA, mouse
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Parvalbumins
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Plant Lectins
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Proteins
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RNA, Untranslated
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Transcription Factors
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tomato lectin
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Tetrodotoxin
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gamma-Aminobutyric Acid
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Choline O-Acetyltransferase
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Glutamate Decarboxylase
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glutamate decarboxylase 2