Abstract
We report the first outbreak of carbapenem-resistant NDM-1-producing Acinetobacter baumannii in Europe, in a French intensive-care unit in January to May 2013. The index patient was transferred from Algeria and led to the infection/colonisation of five additional patients. Concurrently, another imported case from Algeria was identified. The seven isolates were genetically indistinguishable, belonging to ST85. The bla(NDM-1) carbapenemase gene was part of the chromosomally located composite transposon Tn125. This report underscores the growing concern about the spread of NDM-1-producing A. baumannii in Europe.
MeSH terms
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Acinetobacter Infections / diagnosis
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Acinetobacter Infections / drug therapy
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Acinetobacter Infections / epidemiology*
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Acinetobacter Infections / transmission
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Acinetobacter baumannii / drug effects
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Acinetobacter baumannii / genetics
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Acinetobacter baumannii / isolation & purification*
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Aged
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Aged, 80 and over
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Anti-Bacterial Agents / therapeutic use
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Carbapenems / therapeutic use
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Carrier State / microbiology
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Contact Tracing
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Cross Infection / drug therapy
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Cross Infection / epidemiology*
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Cross Infection / transmission
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DNA, Bacterial / genetics
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Disease Outbreaks*
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Drug Resistance, Multiple, Bacterial
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Female
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France / epidemiology
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Humans
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Intensive Care Units
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Male
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Microbial Sensitivity Tests
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Middle Aged
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Travel
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beta-Lactamases / metabolism*
Substances
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Anti-Bacterial Agents
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Carbapenems
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DNA, Bacterial
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beta-Lactamases
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beta-lactamase NDM-1