Identification of malate dehydrogenase 2 as a target protein of the HIF-1 inhibitor LW6 using chemical probes

Angew Chem Int Ed Engl. 2013 Sep 23;52(39):10286-9. doi: 10.1002/anie.201304987. Epub 2013 Aug 9.

Authors

Kyeong Lee¹, Hyun Seung Ban, Ravi Naik, Ye Seul Hong, Seohyun Son, Bo-Kyung Kim, Yan Xia, Kyung Bin Song, Hong-Sub Lee, Misun Won

Affiliation

¹ College of Pharmacy, Dongguk University-Seoul, 26 Pildong, Junggu, Seoul 100-715 (Korea).

PMID: 23934700
DOI: 10.1002/anie.201304987

No abstract available

Keywords: HIF inhibitors; click chemistry; fluorescent probes; malate dehydrogenase 2; photoaffinity labeling.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Line, Tumor
Click Chemistry
Humans
Hypoxia-Inducible Factor 1 / antagonists & inhibitors*
Malate Dehydrogenase / antagonists & inhibitors
Malate Dehydrogenase / metabolism*
Mitochondria / drug effects
Mitochondria / metabolism
Photoaffinity Labels / analysis
Photoaffinity Labels / chemical synthesis
Photoaffinity Labels / metabolism*
Protein Binding

Substances

Hypoxia-Inducible Factor 1
Photoaffinity Labels
Malate Dehydrogenase