A somatic mutation of the KEAP1 gene in malignant melanoma is involved in aberrant NRF2 activation and an increase in intrinsic drug resistance

J Invest Dermatol. 2014 Feb;134(2):553-556. doi: 10.1038/jid.2013.343. Epub 2013 Aug 12.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line, Tumor
  • Drug Resistance, Neoplasm / genetics*
  • Frameshift Mutation
  • Humans
  • Intracellular Signaling Peptides and Proteins / genetics*
  • Intracellular Signaling Peptides and Proteins / metabolism
  • Kelch-Like ECH-Associated Protein 1
  • Melanoma / genetics*
  • Melanoma / metabolism
  • Mutation, Missense
  • NF-E2-Related Factor 2 / metabolism*
  • Skin Neoplasms / genetics*
  • Skin Neoplasms / metabolism

Substances

  • Intracellular Signaling Peptides and Proteins
  • KEAP1 protein, human
  • Kelch-Like ECH-Associated Protein 1
  • NF-E2-Related Factor 2
  • NFE2L2 protein, human