Giant cell reparative granuloma of the pediatric cranium: case report and review of the literature

Childs Nerv Syst. 2014 Mar;30(3):521-6. doi: 10.1007/s00381-013-2254-x. Epub 2013 Aug 13.

Abstract

Purpose: Giant cell reparative granulomas are rare bone tumors. Although benign, these tumors are locally destructive and can be highly vascular. They seldom occur in the cranial vault. We describe a multidisciplinary approach to a case of giant cell reparative granuloma of the cranium in a 3-year-old patient.

Case report: A 3-year-old girl female referred to the pediatric neurosurgery department for evaluation of a retro-auricular mass. She had a history of recurrent otitis media with two subsequent courses of antibiotics without resolution. CT imaging revealed an expansive lesion located in the right mastoid region. Open surgical biopsy revealed a hemorrhagic tumor consistent with a giant cell reparative granuloma. Angiography identified a hypervascular tumor blush that was supplied by the occipital artery. Preoperative transcatheter embolization was performed followed by a multidisciplinary surgical resection and reconstruction. Blood loss was minimal, and the patient recovered well after surgery.

Conclusion: Preoperative endovascular embolization and a multidisciplinary intraoperative approach with primary resection and cranial vault reconstruction is an effective approach to hypervascular giant cell reparative granulomas.

Publication types

  • Case Reports

MeSH terms

  • Biopsy
  • Cerebral Angiography
  • Child, Preschool
  • Diagnosis, Differential
  • Embolization, Therapeutic
  • Female
  • Granuloma, Giant Cell / pathology*
  • Granuloma, Giant Cell / surgery
  • Humans
  • Magnetic Resonance Imaging
  • Neurosurgical Procedures / methods
  • Patient Care Planning
  • Patient Care Team
  • Postoperative Complications / prevention & control
  • Risk Reduction Behavior
  • Skull / surgery
  • Skull Neoplasms / pathology*
  • Skull Neoplasms / surgery
  • Tomography, X-Ray Computed
  • Treatment Outcome