Three novel xanthones from Garcinia paucinervis and their anti-TMV activity

Molecules. 2013 Aug 13;18(8):9663-9. doi: 10.3390/molecules18089663.

Abstract

Phytochemical investigations of the leaves of Garcinia paucinervis resulted in the isolation of three new xanthones 1-3 and five known analogues 4-8. Structural elucidations of 1-3 were performed by spectral methods such as 1D and 2D (HMQC, HMBC, and ROESY) NMR spectroscopy, in addition to high resolution mass spectrometry. Compounds 1-3 showed anti-TMV activities, with inhibition rates above 20%, especially for 1, which had a lower IC₅₀ value of 21.4 µM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antiviral Agents / chemistry
  • Antiviral Agents / pharmacology
  • Garcinia / chemistry*
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Molecular Structure
  • Tobacco Mosaic Virus / drug effects*
  • Xanthones / chemistry
  • Xanthones / isolation & purification*
  • Xanthones / pharmacology*

Substances

  • Antiviral Agents
  • Xanthones