Abstract
Novel silica nanoparticles mimicking virus surface topography are prepared. It is demonstrated that increases in nanoscale surface roughness promote both binding of biomolecules and cellular uptake; thus, the cellular delivery efficiency is significantly increased (scale bars 20 μm).
Keywords:
biomimetic synthesis; drug delivery; nanoparticles; surface topography.
© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Biocompatible Materials / chemistry
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Biocompatible Materials / metabolism
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Carbocyanines / chemistry
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Carbocyanines / metabolism
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Cell Cycle Proteins / antagonists & inhibitors
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Cell Cycle Proteins / genetics
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Cell Cycle Proteins / metabolism
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Cell Line, Tumor
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Cell Survival / drug effects
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Drug Carriers / chemistry*
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Drug Carriers / toxicity
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HeLa Cells
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Humans
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MCF-7 Cells
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Microscopy, Confocal
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Nanoparticles / chemistry*
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Nanoparticles / toxicity
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Oligonucleotides / chemistry
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Oligonucleotides / metabolism
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Polo-Like Kinase 1
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Polyethyleneimine / chemistry
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Protein Serine-Threonine Kinases / antagonists & inhibitors
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Protein Serine-Threonine Kinases / genetics
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Protein Serine-Threonine Kinases / metabolism
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Proto-Oncogene Proteins / antagonists & inhibitors
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Proto-Oncogene Proteins / genetics
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Proto-Oncogene Proteins / metabolism
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RNA Interference
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RNA, Small Interfering / metabolism
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Silicon Dioxide / chemistry*
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Surface Properties
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rab GTP-Binding Proteins / antagonists & inhibitors
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rab GTP-Binding Proteins / genetics
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rab GTP-Binding Proteins / metabolism
Substances
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Biocompatible Materials
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Carbocyanines
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Cell Cycle Proteins
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Drug Carriers
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Oligonucleotides
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Proto-Oncogene Proteins
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RAB33A protein, human
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RNA, Small Interfering
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cyanine dye 3
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Silicon Dioxide
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Polyethyleneimine
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Protein Serine-Threonine Kinases
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rab GTP-Binding Proteins