The kinase-independent, second life of CDK6 in transcription

Cancer Cell. 2013 Aug 12;24(2):141-3. doi: 10.1016/j.ccr.2013.07.019.

Abstract

CDK6 is an oncogenic kinase regulating the cell cycle. In this issue of Cancer Cell, Kollmann and colleagues demonstrate that CDK6 performs a kinase-independent transcriptional function in regulating expression of VEGF-A and p16INK4a. These observations link the cell cycle machinery and angiogenesis and reveal the presence of a fail-safe antiproliferative mechanism.

Publication types

  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Animals
  • Cyclin-Dependent Kinase 6 / metabolism*
  • Humans
  • Neoplasms / blood supply*
  • Neoplasms / enzymology*

Substances

  • Cyclin-Dependent Kinase 6