[Occurrence of subdural hematoma closely associated with danazol administration in a patient with refractory ITP]

K Shinmyozu; T Okadome; Y Maruyama; I Maruyama; M Osame; M Tara

[Occurrence of subdural hematoma closely associated with danazol administration in a patient with refractory ITP]

Rinsho Ketsueki. 1990 May;31(5):674-5.

[Article in Japanese]

Authors

K Shinmyozu¹, T Okadome, Y Maruyama, I Maruyama, M Osame, M Tara

Affiliation

¹ Third Department of Internal Medicine, Faculty of Medicine, Kagoshima, Japan.

PMID: 2395216

Abstract

We reported a 34-year-old female patient with refractory idiopathic thrombocytopenic purpura (ITP) in whom a subacute subdural hematoma occurred without any preceding trauma during danazol administration which resulted in a marked decrease of plasma fibrinogen level. It is strongly suggested that danazol should be very carefully administered in ITP patients with serious bleeding tendency.

Publication types

Case Reports
English Abstract

MeSH terms

Adult
Antithrombin III / analysis
Danazol / adverse effects*
Female
Fibrinogen / analysis
Hematoma, Subdural / chemically induced*
Humans
Pregnadienes / adverse effects*
Protein C / analysis
Purpura, Thrombocytopenic / blood
Purpura, Thrombocytopenic / drug therapy*

Substances

Pregnadienes
Protein C
Antithrombin III
Fibrinogen
Danazol