Diabetic ketoacidosis at diagnosis in Austrian children: a population-based analysis, 1989-2011

J Pediatr. 2013 Nov;163(5):1484-8.e1. doi: 10.1016/j.jpeds.2013.06.033. Epub 2013 Aug 15.

Abstract

Objective: To analyze the effect of a community-based, poster-focused prevention program on the frequency of diabetic ketoacidosis (DKA) at diabetes onset in Austria.

Study design: All newly diagnosed patients with diabetes ≤ 15 years of age were registered prospectively by the Austrian Diabetes Incidence Study Group. Registered data included initial blood glucose, pH, and ketonuria. DKA was defined as pH < 7.3 and severe DKA as pH < 7.1. Data between 1989 and 2011 were available. In autumn, 2009, a community-based prevention program similar to the Parma Campaign, in which posters were dispensed broadly, was initiated. The frequency of DKA at the onset of diabetes in the years 2005-2009 and 2010-2011 was compared.

Results: During the study period, 4038 children were registered. A total of 37.2% presented with DKA; 26% had a mild and 11.2% a severe form. The frequency of DKA was negatively associated with age at onset. In the years before the intervention program, 26% had mild DKA compared with 27% after the intervention (not significant). The prevalence of severe DKA in the years before the campaign was 12% compared with 9.5% thereafter (not significant). No significant change in the DKA rate at onset by the prevention program could be found when we compared age groups <5, 5 to <10, and 10 to <15 years, neither for mild nor for severe DKA.

Conclusion: The frequency of DKA in children with newly diagnosed type 1 diabetes in Austria is high and did not change despite the efforts of a community-based information program.

Keywords: DKA; DMT1; Diabetic ketoacidosis; Type 1 diabetes mellitus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Age of Onset
  • Austria / epidemiology
  • Blood Glucose / analysis
  • Child
  • Child, Preschool
  • Community Health Services
  • Diabetes Mellitus, Type 1 / blood
  • Diabetes Mellitus, Type 1 / diagnosis*
  • Diabetic Ketoacidosis / diagnosis*
  • Diabetic Ketoacidosis / epidemiology*
  • Diabetic Ketoacidosis / prevention & control
  • Female
  • Health Communication
  • Humans
  • Hydrogen-Ion Concentration
  • Incidence
  • Ketosis / diagnosis
  • Male
  • Outcome Assessment, Health Care
  • Preventive Medicine / methods
  • Prospective Studies
  • Public Health
  • Registries

Substances

  • Blood Glucose