Calcium signaling: septins organize the SOC channel

James W Putney Jr

doi:10.1016/j.cub.2013.07.042

Calcium signaling: septins organize the SOC channel

Curr Biol. 2013 Aug 19;23(16):R684-5. doi: 10.1016/j.cub.2013.07.042.

Author

James W Putney Jr¹

Affiliation

¹ Laboratory of Signal Transduction, National Institute of Environmental Health Sciences - NIH, Department of Health and Human Services, Research Triangle Park, NC 27709, USA. [email protected]

PMID: 23968922
DOI: 10.1016/j.cub.2013.07.042

Abstract

Store-operated Ca(2+) entry is a widely encountered mechanism for generating cytoplasmic Ca(2+) signals. From a whole-genome screen in HeLa cells, a new study reveals that cytoskeletal septins play a critical role in this process, by organizing signaling structures in the plasma membrane.

Publication types

Comment

MeSH terms

Calcium / metabolism*
Humans
NFATC Transcription Factors / metabolism*
RNA Interference*
RNA, Small Interfering / genetics*
Septins / metabolism*

Substances

NFATC Transcription Factors
RNA, Small Interfering
Septins
Calcium