Structural Biology: Parkin's Serpentine Shape Revealed in the Year of the Snake

Curr Biol. 2013 Aug 19;23(16):R691-3. doi: 10.1016/j.cub.2013.07.039.

Abstract

Parkin is an E3 ubiquitin ligase, mutations in which are responsible for autosomal recessive juvenile parkinsonism. Recently, several structures of Parkin have been solved, revealing its serpentine shape and modes of auto-inhibition.

MeSH terms

  • Animals
  • Models, Molecular
  • Mutation
  • Protein Conformation
  • Protein Folding
  • Protein Structure, Tertiary
  • Rats
  • Ubiquitin-Protein Ligases / chemistry*
  • Ubiquitin-Protein Ligases / genetics
  • Ubiquitin-Protein Ligases / metabolism*

Substances

  • Ubiquitin-Protein Ligases
  • parkin protein