Androgenetic alopecia: an update

Indian J Dermatol Venereol Leprol. 2013 Sep-Oct;79(5):613-25. doi: 10.4103/0378-6323.116730.

Abstract

Androgenetic alopecia (AGA) is one of the commonest reasons for dermatological consultation. Over the last few years our understanding of the pathophysiology of AGA has improved and this has paved way for better diagnostic and therapeutic options. Recent research has dwelled on the role of stem cells in the pathophysiology of AGA and has also identified newer genetic basis for the condition. Dermoscopy/trichoscopy has emerged as a useful diagnostic tool for AGA. While the major treatment options continue to be topical minoxidil, systemic Finasteride and hair transplantations, newer modalities are under investigation. Specific diagnostic and treatment recommendations have also been developed on evidence based principles. This article reviews the recent concepts in relation to AGA. With regards to the pathophysiology we have tried to stress on recent knowledge of the molecular and genetic basis of AGA. We have emphasized on an evidence based approach for treatment and diagnosis.

Publication types

  • Review

MeSH terms

  • 5-alpha Reductase Inhibitors / therapeutic use
  • Alopecia / diagnosis*
  • Alopecia / drug therapy*
  • Alopecia / physiopathology
  • Diagnosis, Differential
  • Female
  • Finasteride / therapeutic use*
  • Humans
  • Male
  • Minoxidil / therapeutic use*
  • Vasodilator Agents / therapeutic use

Substances

  • 5-alpha Reductase Inhibitors
  • Vasodilator Agents
  • Finasteride
  • Minoxidil