The mitochondrial genome of Paramphistomum cervi (Digenea), the first representative for the family Paramphistomidae

PLoS One. 2013 Aug 22;8(8):e71300. doi: 10.1371/journal.pone.0071300. eCollection 2013.

Abstract

We determined the complete mitochondrial DNA (mtDNA) sequence of a fluke, Paramphistomum cervi (Digenea: Paramphistomidae). This genome (14,014 bp) is slightly larger than that of Clonorchis sinensis (13,875 bp), but smaller than those of other digenean species. The mt genome of P. cervi contains 12 protein-coding genes, 22 transfer RNA genes, 2 ribosomal RNA genes and 2 non-coding regions (NCRs), a complement consistent with those of other digeneans. The arrangement of protein-coding and ribosomal RNA genes in the P. cervi mitochondrial genome is identical to that of other digeneans except for a group of Schistosoma species that exhibit a derived arrangement. The positions of some transfer RNA genes differ. Bayesian phylogenetic analyses, based on concatenated nucleotide sequences and amino-acid sequences of the 12 protein-coding genes, placed P. cervi within the Order Plagiorchiida, but relationships depicted within that order were not quite as expected from previous studies. The complete mtDNA sequence of P. cervi provides important genetic markers for diagnostics, ecological and evolutionary studies of digeneans.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Base Sequence
  • Bayes Theorem
  • DNA Primers
  • DNA, Mitochondrial / genetics
  • Gene Order
  • Genetic Markers
  • Genetic Variation
  • Genome, Mitochondrial*
  • Molecular Sequence Data
  • Nucleic Acid Conformation
  • Open Reading Frames
  • Paramphistomatidae / genetics*
  • Phylogeny
  • RNA, Transfer / genetics
  • RNA, Untranslated / genetics
  • Sequence Analysis, Protein

Substances

  • DNA Primers
  • DNA, Mitochondrial
  • Genetic Markers
  • RNA, Untranslated
  • RNA, Transfer

Grants and funding

This study was supported by the “Special Fund for Agro-scientific Research in the Public Interest” (Grant No. 201303037), the Science Fund for Creative Research Groups of Gansu Province (Grant No. 1210RJIA006), and NBCITS, MOA (CARS-38), the People's Republic of China. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript