Abstract
A patient with aplastic anaemia, successively treated with caspofungin then liposomal amphotericin, developed a disseminated infection due to Acremonium, further confirmed as resistant in vitro to these drugs. Successful treatment was achieved with voriconazole. Multiple antifungal treatments may expose to the risk of breakthrough of multi-resistant pathogens in haematology patients.
Keywords:
Acremonium; amphotericin B resistance; caspofungin resistance; opportunistic infections; severe aplastic anaemia.
© 2013 The Authors Clinical Microbiology and Infection © 2013 European Society of Clinical Microbiology and Infectious Diseases.
MeSH terms
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Acremonium / classification
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Acremonium / isolation & purification*
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Adult
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Amphotericin B / therapeutic use*
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Anemia, Aplastic / complications*
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Anemia, Aplastic / microbiology
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Antifungal Agents / therapeutic use*
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Caspofungin
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Drug Resistance, Fungal / drug effects
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Echinocandins / therapeutic use*
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Humans
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Lipopeptides
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Male
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Mycoses / drug therapy
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Mycoses / microbiology*
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Opportunistic Infections / drug therapy
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Opportunistic Infections / microbiology*
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Pyrimidines / pharmacology*
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Pyrimidines / therapeutic use
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Triazoles / pharmacology*
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Triazoles / therapeutic use
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Voriconazole
Substances
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Antifungal Agents
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Echinocandins
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Lipopeptides
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Pyrimidines
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Triazoles
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Amphotericin B
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Caspofungin
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Voriconazole