A role for angiopoietin-2 in organ-specific metastasis

Cell Rep. 2013 Aug 29;4(4):621-3. doi: 10.1016/j.celrep.2013.07.034.

Abstract

Angiopoietin-2 (ANG2/ANGPT2) has recently emerged as a promising target for the inhibition of tumor metastasis. In this issue of Cell Reports, Minami et al. show that the calcineurin-NFAT pathway promotes pulmonary tumor metastasis by inducing ANG2 in the lung endothelium.

Publication types

  • Comment

MeSH terms

  • Animals
  • Calcineurin / metabolism*
  • Humans
  • Lung / metabolism*
  • Lung Neoplasms / metabolism*
  • NFATC Transcription Factors / metabolism*
  • Ribonuclease, Pancreatic / metabolism*

Substances

  • NFATC Transcription Factors
  • Ang2 protein, mouse
  • Ribonuclease, Pancreatic
  • Calcineurin