Abstract
Five new labdane diterpenes (1-5), serralabdanes A-E, were isolated from the whole plant of Chloranthus serratus. Their structures were elucidated by spectroscopic methods, and the absolute configuration of the 12,13-diol moiety in serralabdane C (3) was determined by observing the induced circular dichroism (ICD) after addition of dimolybdenum teracetate in DMSO solution. Serralabdanes A-E (1-5) showed inhibitory effects on lipopolysaccharide-induced nitric oxide production in RAW264.7 cells.
Keywords:
Anti-inflammatory; Chloranthus serratus; Induced circular dichroism; Labdane diterpene.
© 2013.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Inflammatory Agents / chemistry
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Anti-Inflammatory Agents / isolation & purification
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Anti-Inflammatory Agents / pharmacology
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Anti-Inflammatory Agents / therapeutic use
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Diterpenes / chemistry
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Diterpenes / isolation & purification*
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Diterpenes / pharmacology
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Diterpenes / therapeutic use
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Inflammation / chemically induced
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Inflammation / drug therapy
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Inflammation / metabolism*
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Lipopolysaccharides
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Macrophages / drug effects
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Macrophages / metabolism
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Magnoliopsida / chemistry*
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Molecular Structure
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Nitric Oxide / biosynthesis
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Phytotherapy
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Plant Extracts / chemistry
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Plant Extracts / pharmacology
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Plant Extracts / therapeutic use
Substances
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Anti-Inflammatory Agents
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Diterpenes
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Lipopolysaccharides
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Plant Extracts
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Nitric Oxide