Abstract
Continuous subcutaneous administration of 16 mg/kg body weight 1,2-dimethylhydrazine three times a month (total dose--1080-3696 mg) to Macaca fascicularis monkeys induced cancer invariably confined to the colon within 34-47 weeks. Biologic, clinical, histologic features and natural course of the tumor proved similar to those of its human counterpart.
Publication types
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Case Reports
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English Abstract
MeSH terms
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1,2-Dimethylhydrazine
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Adenocarcinoma / chemically induced*
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Adenocarcinoma / pathology
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Animals
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Carcinogens / toxicity*
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Dimethylhydrazines / toxicity*
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Dose-Response Relationship, Drug
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Female
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Injections, Subcutaneous
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Intestinal Neoplasms / chemically induced*
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Intestinal Neoplasms / pathology
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Intestine, Large* / pathology
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Lymphatic Metastasis
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Macaca fascicularis
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Male
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Methylhydrazines / toxicity*
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Time Factors
Substances
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Carcinogens
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Dimethylhydrazines
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Methylhydrazines
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1,2-Dimethylhydrazine