Abstract
Synthetic studies on hemicalide, a recently isolated marine natural product displaying highly potent antiproliferative activity and a unique mode of action, have highlighted a reliable Horner-Wadsworth-Emmons olefination to create the C6-C7 alkene and a remarkable efficient Suzuki-Miyaura coupling to form the C15-C16 bond, resulting in the development of a convergent approach toward the C1-C25 fragment.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkenes / chemistry*
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Animals
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology
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Biological Products / chemical synthesis*
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Biological Products / chemistry
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Biological Products / pharmacology
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Marine Biology
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Molecular Structure
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Polyketides / chemical synthesis*
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Polyketides / chemistry
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Polyketides / pharmacology
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Porifera / chemistry
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Stereoisomerism
Substances
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Alkenes
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Antineoplastic Agents
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Biological Products
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Polyketides
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hemicalide