Construction of 2-substituted-3-functionalized benzofurans via intramolecular Heck coupling: application to enantioselective total synthesis of daphnodorin B

Org Lett. 2013 Sep 20;15(18):4742-5. doi: 10.1021/ol4021095. Epub 2013 Sep 5.

Abstract

A novel approach was developed for the synthesis of 2-substituted-3-functionalized benzofurans, using an intramolecular Heck reaction which was further applied in the first enantioselective total synthesis of Daphnodorin B.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Benzofurans / chemical synthesis*
  • Benzofurans / chemistry
  • Benzopyrans / chemical synthesis*
  • Benzopyrans / chemistry
  • Catalysis
  • Molecular Structure
  • Palladium / chemistry
  • Stereoisomerism

Substances

  • Benzofurans
  • Benzopyrans
  • Palladium
  • daphnodorin B