Enhanced glucagon-like peptide-1 secretion in a patient with glucagonoma: implications for glucagon-like peptide-1 secretion from pancreatic α cells in vivo

Diabetes Res Clin Pract. 2013 Oct;102(1):e1-4. doi: 10.1016/j.diabres.2013.08.005. Epub 2013 Aug 19.

Abstract

We examined GLP-1 secretion from the pancreas of a patient with glucagonoma and pancreatic resection by measuring GLP-1 after meal ingestion or selective arterial calcium injection, and immunohistochemical analysis. Our findings support the notion that GLP-1 is secreted from pancreatic α cells in humans.

Keywords: GIP; GLP-1; Glucagon-like peptide-1; Glucagonoma; MEN1; Pancreatic α cells; glucagon-like peptide 1; glucose-dependent insulinotropic polypepide; multiple endocrine neoplasia syndrome, type 1.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Arteries
  • Calcium Gluconate / administration & dosage
  • Food
  • Glucagon / blood
  • Glucagon-Like Peptide 1 / metabolism*
  • Glucagon-Secreting Cells / metabolism*
  • Glucagonoma / metabolism*
  • Glucagonoma / surgery
  • Humans
  • Injections, Intra-Arterial
  • Male
  • Middle Aged
  • Multiple Endocrine Neoplasia Type 1 / complications
  • Pancreatectomy

Substances

  • Glucagon-Like Peptide 1
  • Glucagon
  • Calcium Gluconate