Mammary ovarian metastases with stroma cell hyperplasia and postmenopausal virilization

Cancer. 1990 Sep 15;66(6):1221-4. doi: 10.1002/1097-0142(19900915)66:6<1221::aid-cncr2820660623>3.0.co;2-b.

Abstract

The case of a 57-year-old woman with a history of breast cancer is reported. She presented 10 years later with virilization. Stroma cell hyperplasia was present in the metastatic ovaries. The authors describe hormonal data and discuss the pathogenesis of the stromal activity. Mammary ovarian metastases associated with stroma cell hyperplasia, in the absence of pregnancy, that cause virilization are rare.

Publication types

  • Case Reports

MeSH terms

  • 17-alpha-Hydroxyprogesterone
  • Breast Neoplasms / pathology*
  • Carcinoma / blood
  • Carcinoma / pathology
  • Carcinoma / secondary*
  • Female
  • Humans
  • Hydroxyprogesterones / blood
  • Hyperplasia
  • Menopause*
  • Middle Aged
  • Muscle, Smooth / pathology
  • Ovarian Neoplasms / blood
  • Ovarian Neoplasms / pathology
  • Ovarian Neoplasms / secondary*
  • Ovary / pathology
  • Receptors, Estradiol / analysis
  • Receptors, Progesterone / analysis
  • Testosterone / blood
  • Virilism / etiology*

Substances

  • Hydroxyprogesterones
  • Receptors, Estradiol
  • Receptors, Progesterone
  • Testosterone
  • 17-alpha-Hydroxyprogesterone