A new RING tossed into an old HAT

Alison E Ringel; Cynthia Wolberger

doi:10.1016/j.str.2013.08.011

A new RING tossed into an old HAT

Structure. 2013 Sep 3;21(9):1479-81. doi: 10.1016/j.str.2013.08.011.

Authors

Alison E Ringel¹, Cynthia Wolberger

Affiliation

¹ Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Abstract

p300 and CBP are multi-domain histone acetyltransferases (HATs) that regulate gene expression and are mutated in human diseases including cancer. Delvecchio and colleagues report the structure of the p300 catalytic core, revealing the presence of a previously unknown RING domain that regulates the enzyme's activity.

Publication types

Comment

MeSH terms

Chromatin / metabolism*
Humans
p300-CBP Transcription Factors / chemistry*
p300-CBP Transcription Factors / metabolism*

Substances

Chromatin
p300-CBP Transcription Factors

Grants and funding

R01 GM095822/GM/NIGMS NIH HHS/United States